A Study of Microbiological Profile and Sensitivity Pattern in Patients with Exacerbation of Bronchiectasis in a Tertiary Care Hospital

Bronchiectasis is of clinician’s concern because of its frequent exacerbations. The prevalence is currently increasing, probably due to an increased use of thoracic computed tomography (CT). So, it is very crucial to know the causative organism and the drug sensitivity for a rational and precise treatment. After evaluating the diagnosis of exacerbation of bronchiectasis by clinical and radiological parameters, 50 patients were enrolled in the study, among which FOB done in 41 cases. Microbiological study of sputum and BAL was done to detect the causative organisms and their sensitivity patterns. Pseudomonus aeruginosa and Klebsiella sp. in sputum; and Pseudomonus aeruginosa and Haemophilus influenza in BAL are the most abundant organisms. Carbapenems, Aminoglycosides and Coamoxyclav are the most potent antibiotics. Sputum and BAL were found to have nearly the same efficacy in detection of the pathogenic organisms of LRT. So sputum culture can replace BAL fluid culture in the work up of exacerbation of bronchiectasis.