Serum uric acid and markers of low-density lipoprotein oxidation in nonsmoking healthy subjects: data from the Brisighella Heart Study

Serum uric acid (SUA) levels, an inexpensive and standardized marker of systemic oxidative stress, has been recently associated with the risk of atherosclerotic cardiovascular events. The main objective of the study was to evaluate the possible relationship between SUA, oxidized low-density lipoproteins (oxLDLs) and LDL susceptibility to oxidation in a sample of nonsmoking healthy subjects. From the general database of the Brisighella Heart Study, we selected a sample of 354 nonsmoking and pharmacologically untreated adult subjects, in primary prevention for cardiovascular disease, with normal renal function, and without known allergic or rheumatic diseases, who were visited during the 2008 population survey. A full set of clinical and hematochemical parameters was evaluated together with oxidative susceptibility of LDL and oxLDL levels. In a multivariate analysis, the oxLDL level was positively correlated with apolipoprotein B (ApoB; B = 0.077; 95% confidence interval [CI], 0.015-0.139; P = 0.016), triglicerydes (B = 0.050; 95% CI, 0.032-0.069; P