A 3R’s Research: Rapid Assessment of New Indigenously Made Ventilators in Acute Respiratory Distress Syndrome (ARDS) Induced Rabbits by Non-invasive Method

Background: Laboratory animal models were frequently used to assess the efficiency of newly made ventilators. Assessment of efficiency of these ventilators may be useful for human patients affected with respiratory distress or COVID-19. Methods: Rabbits were randomly divided into four groups viz., negative control, positive control (ARDS induced), induced ARDS and co-treated with referral ventilator (VR), ARDS induced and co-treated with experimental ventilator (VE). The groups were assessed by measuring the BGA, vitals, tidal volume (VT) and other ventilator parameters. Result: SpO2 of control group (98.75±0.25) did not reveal any significant difference with VR -1 hr (97.75±0.63), VR-3 hrs (97.75±0.95), VE-1 hr (96.75±1.11) and VE-3hrs (97.25±0.85). While comparing with other groups, ARDS group (61±7.69) revealed a highly significant decrease (p less than 0.01) in the SpO2 level. PEEP of control and other groups were found to be equal (4±0.00).