Inhibition of osteosarcoma cell proliferation in vitro and tumor growth in vivo in mice model by alstonine through AMPK-activation and PGC-1α/TFAM up-regulation

Inhibition of osteosarcoma cell proliferation in vitro and tumor growth in vivo in mice model by alstonine through AMPK-activation and PGC-1α/TFAM up-regulation

Osteosarcoma, a leading malignant tumor of bones is diagnosed mostly in adolescents and young adults worldwide. The present study investigated alstonine as anti-osteosarcoma agent in vitro as well as in vivo and evaluated the underlying mechanism. Treatment with alstonine led to a significant (P

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Veröffentlicht in:Acta biochimica polonica 2022-08
Hauptverfasser: Yan, Qin, Jiang, Jianfeng, Xie, Jingbo, Jiang, Shengbo, Bai, Yunting
Format: Artikel
Sprache:eng
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Zusammenfassung:Osteosarcoma, a leading malignant tumor of bones is diagnosed mostly in adolescents and young adults worldwide. The present study investigated alstonine as anti-osteosarcoma agent in vitro as well as in vivo and evaluated the underlying mechanism. Treatment with alstonine led to a significant (P
ISSN:0001-527X
1734-154X
DOI:10.18388/abp.2020_5769