The EGFR rs2233947 polymorphism is associated with lung cancer risk: a study from Jordan

The epidermal growth factor receptor (EGFR) is a tyrosine kinase cell surface protein that plays a role in the process of carcinogenesis. In this study, we investigated the association between EGFR rs2233947 and rs884225 SNPs and the risk of lung cancer. A total of 258 participants (129 lung cancer...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta biochimica Polonica 2019-09, Vol.66 (3), p.315
Hauptverfasser:	Bashir, Nabil A, Morad, Farah R, Khabour, Omar F, AlFaqih, Mahmoud A, Khassawneh, Basheer Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amplified Fragment Length Polymorphism Analysis Carcinoma, Squamous Cell - genetics Case-Control Studies ErbB Receptors - genetics Female Gene Frequency - genetics Genetic Predisposition to Disease Genotype Haplotypes Humans Jordan Lung Neoplasms - genetics Male Middle Aged Polymorphism, Restriction Fragment Length - genetics Polymorphism, Single Nucleotide - genetics Sex Factors Smoking - adverse effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The epidermal growth factor receptor (EGFR) is a tyrosine kinase cell surface protein that plays a role in the process of carcinogenesis. In this study, we investigated the association between EGFR rs2233947 and rs884225 SNPs and the risk of lung cancer. A total of 258 participants (129 lung cancer patients and 129 healthy controls) took part in the study. Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique was used to genotype EGFR SNPs. A strong association was detected between rs2233947 and lung cancer (P
ISSN:	0001-527X 1734-154X
DOI:	10.18388/abp.2019_2781