Atrial natriuretic peptide suppresses compensatory renal growth in rats

Atrial natriuretic peptide (ANP) inhibits the growth of a variety of cell types in vitro including mesangial cells. The effects of ANP on the growth of the kidney in vivo were evaluated. A 2-h infusion of 0.2 microgram/250 g body wt per minute of ANP suppressed the subsequent uptake of [3H]thymidine...

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Veröffentlicht in:	Journal of the American Society of Nephrology 1994-06, Vol.4 (12), p.2016-2022
Hauptverfasser:	Logan, J L, Michael, U F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Natriuretic Factor - pharmacology Body Weight - drug effects DNA - analysis Glomerular Filtration Rate Hypertrophy Kidney - drug effects Kidney - pathology Male Mitosis - drug effects Nephrectomy Organ Size - drug effects Rats Rats, Sprague-Dawley
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Zusammenfassung:	Atrial natriuretic peptide (ANP) inhibits the growth of a variety of cell types in vitro including mesangial cells. The effects of ANP on the growth of the kidney in vivo were evaluated. A 2-h infusion of 0.2 microgram/250 g body wt per minute of ANP suppressed the subsequent uptake of [3H]thymidine into the renal DNA of uninephrectomized but not intact rats. This treatment also depressed the ratio of RNA/DNA in kidneys undergoing compensatory growth. Correlative physiologic studies revealed enhanced GFR in rats with two kidneys infused with ANP, but no increase in the GFR of uninephrectomized rats. It was concluded that ANP may oppose the growth factor(s) mediating compensatory renal growth.
ISSN:	1046-6673
DOI:	10.1681/ASN.V4122016