Captopril-induced fall in glomerular filtration rate in cyclosporine-treated hypertensive patients

Captopril-induced fall in glomerular filtration rate in cyclosporine-treated hypertensive patients

It was found that two known renal vasodilators had different effects on RBF and GFR in the setting of therapeutic blood levels of cyclosporine in hypertensive renal transplant patients. Captopril lowered blood pressure in these patients but also lowered blood flow and GFR. Nifedipine lowered blood p...

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Veröffentlicht in:Journal of the American Society of Nephrology 1993-03, Vol.3 (9), p.1570-1574
Hauptverfasser: Curtis, J J, Laskow, D A, Jones, P A, Julian, B A, Gaston, R S, Luke, R G
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood Pressure - drug effects
Captopril - therapeutic use
Cyclosporine - therapeutic use
Female
Glomerular Filtration Rate - drug effects
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Kidney Transplantation
Male
Nifedipine - therapeutic use
Postoperative Period
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Zusammenfassung:It was found that two known renal vasodilators had different effects on RBF and GFR in the setting of therapeutic blood levels of cyclosporine in hypertensive renal transplant patients. Captopril lowered blood pressure in these patients but also lowered blood flow and GFR. Nifedipine lowered blood pressure to the same degree but without lowering either RBF or GFR.
ISSN:1046-6673
DOI:10.1681/ASN.V391570