Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule

The aim of this study was to define mechanisms involved in the luminal uptake of inorganic mercury in the kidney using isolated perfused straight (S2) segments of the proximal tubule. When mercuric conjugates of glutathione (GSH), cysteinylglycine. or cysteine (containing 203Hg2+) were perfused thro...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2000-03, Vol.11 (3), p.394-402
Hauptverfasser:	CANNON, V. T, BARFUSS, D. W, ZALUPS, R. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cilastatin - pharmacology Cysteine - physiology Dipeptidases - antagonists & inhibitors Dipeptidases - physiology Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase - antagonists & inhibitors gamma-Glutamyltransferase - physiology Glutathione - pharmacokinetics In Vitro Techniques Isoxazoles - pharmacology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Mercury - pharmacokinetics Protease Inhibitors - pharmacology Rabbits Sequence Homology, Amino Acid Vertebrates: urinary system
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