Experimental Cytological Study of Kidney-epithelium of the Rats

The author has investigated the function of the uriniferous tubules in abnormal metabolism, especially in the case of poisoning, placing the principal object on the mitochondria. For this purpose the author performed the following experiments: 1. D.A.B (p-dimethylaminoazobenzene, i. e. butter yellow) was given for a long term as the experiment of chronic poisoning. 2. The D.A.B. -diet was stopped on the 30th day, then normal food was given and the recovery of the cell was observed. 3. An olive oil diet, a diet which contains everything in the D.A. B. -diet except D.A.B., was given to observe the effect of D.A.B. alone and at the same time to make comparison. Comparative observations were performed after the injections of a large, a intermediate and a small amount of Neo-Neo-Arsemin (Arsenobenzol-Natrium) which is an arsenic compound, as the experiments of acute poisoning. According to the results of these experiments, it was demonstrated that the changes following the poisoning were most marked in the portio principalis. The portio principalis could be divided into 3 parts-the proximal part, the distal part from the glomerulum and the intermediate part in between - according to the minute structure of the cells and their characteristic changes. Their special functions and rôles played in urine secretion were also demonstrated.