Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo

Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo

Treatment of type 1 diabetes by islet transplantation is currently limited by loss of functional β-cell mass after transplantation. We investigated here whether adenovirus-mediated changes in AMP-activated protein kinase (AMPK) activity, previously shown to affect insulin secretion in vitro, might a...

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Veröffentlicht in:Journal of endocrinology 2005-11, Vol.187 (2), p.225-235
Hauptverfasser: Richards, S K, Parton, L E, Leclerc, I, Rutter, G A, Smith, R M
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Regular papers
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Zusammenfassung:Treatment of type 1 diabetes by islet transplantation is currently limited by loss of functional β-cell mass after transplantation. We investigated here whether adenovirus-mediated changes in AMP-activated protein kinase (AMPK) activity, previously shown to affect insulin secretion in vitro, might affect islet graft function in vivo. In isolated mouse and rat islets, insulin secretion stimulated by 17 (vs 3) mmol/l glucose was inhibited by 36.5% (P
ISSN:0022-0795
1479-6805
DOI:10.1677/joe.1.06413