On the Rôle of the Augmented Adrenaline Secretion from the Suprarenal Glands after Inhalation of Carbon Monoxide upon the Fluctuation of the Blood Sugar Content and the Blood Pressure Simultaneously Occurring

To know what a part is played by accelerated adrenaline secretion in carbon monoxide anoxia in the fluctuation of blood sugar content and of blood pressure, the present investigations were undertaken. Three series of experiments were carried out; (1) 3% carbon mono-oxide was inhaled in normal dogs. (2) The same was done in dogs with the demedullated suprarenals. (3) Continuous adrenaline infusion, which imitated the natural adrenaline secretion augmented by carbon monoxide was performed in dogs with the demedullated suprarenals. All experiments were carried out without narcotizing or fastening. After inhalation of carbon monoxide, a remarkable hyperglycemia and elevation of the blood pressure were observed in normal dogs as well as in those with the demedullated suprarenals. The magnitude of hyper-glycemia in dogs with the demedullated suprarenals was somewhat smaller than that in normal dogs. It was difficult to find any definite difference in the magnitude of blood pressure changes between the normal and the operated animals. From the evidence given above it may be justifiable to conclude that the augmented adrenaline secretion from the suprarenal medulla plays a small part in the hyperglycemia produced by carbon monoxide poison-ing.