Adrenaline Load of the Suprarenal Glands of Rabbits in Histamine Poisoning

From the evidence reported by Satow that the glycemic action of histamine is quite different, in using the different manner. of applications, the interest was evoked, and the present studies were undertaken to know whether the similar evidence can be found or not concerning, the influence of histamine upon the adrenaline load of the suprarenal. gland. Rabbits were used. The adrenaline load of the suprarenal glands was estimated by the corrosive sublimate method of Suto-Kojima. Histamine was injected intravenously in a dose of 0.5mg per kg of body weight in 10 seconds or in 60 seconds. Some rabbits died several minutes after histamine injection and others were able to recover. In the former the suprarenals were removed soon after death and in the latter it was removed 30 minutes after injection. In these experiments we could not find any definite alteration of adrenaline load after histamine. Subcutaneous in-jection of histamine in a dose of 20mg per kg was also applied. In this series of experiments the reduction of adrenaline load was observed.