Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy

To evaluate hemodynamics and bispectral index (BIS) in bitches anesthetized with ketamine and midazolam in combination with dexmedetomidine or medetomidine and submitted to ovariohysterectomy. Twenty bitches pretreated with levomedetomidine and buprenorphine were anesthetized with 5 mg*kg(-1) ketamine and 0.2 mg*kg(-1) midazolam i.v. Continuous infusion of 0.4 mg*kg(-1)*h(-1) midazolam and 20 mg*kg(-1)*h(-1) ketamine was initiated in combination with DEX (n=10): 20 microg*kg(-1)*h(-1) dexmedetomidine or MED (n=10): 30 microg*kg(-1)*h(-1) medetomidine over 30 minutes. A pharmacokinetic study provided dexmedetomidine plasma concentration, set to be 3.0 ng*mL(-1). BIS decreased in both groups (P