SYNTHESIS OF FLUORINATED BENZOTHIAZOLES, STUDY OF THEIR LITHIATION SITES AND SUBSEQUENT INTERACTION WITH DIMETHYLFORMAMIDE

SYNTHESIS OF FLUORINATED BENZOTHIAZOLES, STUDY OF THEIR LITHIATION SITES AND SUBSEQUENT INTERACTION WITH DIMETHYLFORMAMIDE

The interaction of 4,6-difluoro-, 4-fluoro-, and 2-bromo-4,6-difluorobenzothiazole with BuLi and LiN[(CH3)3Si]2 in THF, followed by the treatment with dimethylformamide or MeI, revealed the main metalation sites in these model mono- and difluorinated benzothiazoles. The reactivity of the resulting L...

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Veröffentlicht in:Chemistry for Sustainable Development 2023-12, Vol.31 (6), p.673-680
Hauptverfasser: V.E., ROMANOV, E.V., PANTELEEVA
Format: Artikel
Sprache:eng
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Zusammenfassung:The interaction of 4,6-difluoro-, 4-fluoro-, and 2-bromo-4,6-difluorobenzothiazole with BuLi and LiN[(CH3)3Si]2 in THF, followed by the treatment with dimethylformamide or MeI, revealed the main metalation sites in these model mono- and difluorinated benzothiazoles. The reactivity of the resulting Li-derivatives with respect to formylation and methylation was also described.
ISSN:1817-1818
1817-1818
DOI:10.15372/CSD2023516