Hypertension in resposible for brain catecholamine which modulated by androgen and estrogen

(1). In male, androgen facilitates release of NE from hypothalamus and orchiectomy-induce reduction of BP coincidently, the NErelease is retardated. (2) In female, ovariectomy-induce reduction of BP contraly, the NE-release is enhanced suggesting lack of estrogen lead to an increase in intrinsic NE and this, in turn, inhibits BP because the sensitivity of postsynaptic receptor is enhanced by estrogen. (3). It is suggesting that the mechanismus of control of BP by hypothalamic NE is regulated with different actions between androgen and estrogen.