Evaluation of Serum, Saliva and GCF Visfatin Levels in Chronic Periodontitis Patients with Uncontrolled /Controlled Type2 Diabetes Mellitus

Background: Visfatin is a multifaceted protein that plays an important role in diabetes (DM) and periodontitis (CP). It has been known that during inflammation, the production of IL-1b, TNF-a can be induced by visfatin. Therefore, visfatin is an important mediator for both diseases. The aim of this study is to investigation of visfatin levels in serum, saliva and GCF samples of non-diabetic periodontitis patients and controlled and uncontrolled diabetic periodontitis patients, and evaluation of the relationship with clinical and biochemical parameters of periodontitis Methods: Study protocol, 5 groups which each one were consisted of 15 subjects were planned: periodontally healthy patients with systemically healthy (DM-P-); patients with systemically healthy and CP (DM-P+), periodontally healthy patients with diabetes (DM+P-), patients with diabetes and CP (DM+P+), patients with uncontrolled diabetes and CP (uDM+P). Serum, saliva and GCF samples were obtained and, levels of visfatin, TNF-α and IL-1β were determined by ELISA. Results: The highest visfatin, TNF-α and IL-1β levels were seen in (uDM+P+) group (p>0.001). Significant positive correlations between GCF visfatin levels and GCF TNF-α and IL-1β levels were detected in (uDM+P+) group (p Background: Visfatin is a multifaceted protein that plays an important role in diabetes (DM) and periodontitis (CP). It has been known that during inflammation, the production of IL-1b, TNF-a can be induced by visfatin. Therefore, visfatin is an important mediator for both diseases. The aim of this study is to investigation of visfatin levels in serum, saliva and GCF samples of non-diabetic periodontitis patients and controlled and uncontrolled diabetic periodontitis patients, and evaluation of the relationship with clinical and biochemical parameters of periodontitis Methods: Study protocol, 5 groups which each one were consisted of 15 subjects were planned: periodontally healthy patients with systemically healthy (DM-P-); patients with systemically healthy and CP (DM-P+), periodontally healthy patients with diabetes (DM+P-), patients with diabetes and CP (DM+P+), patients with uncontrolled diabetes and CP (uDM+P). Serum, saliva and GCF samples were obtained and, levels of visfatin, TNF-α and IL-1β were determined by ELISA. Results: The highest visfatin, TNF-α and IL-1β levels were seen in (uDM+P+) group (p>0.001). Significant positive correlations between GCF visfatin levels and GCF TNF-α and IL-1β levels were detect