Nitric oxide mediates abnormal responsiveness of thyroid arteries in methimazole-treated patients

Objective: We studied the intervention of nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) in mediating responses to acetylcholine in thyroid arteries from euthyroid and methimazole-treated (MT) patients. Design and methods: Branches of the superior thyroid arter...

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Veröffentlicht in:	European journal of endocrinology 2005-04, Vol.152 (4), p.551-556
Hauptverfasser:	Ortega, Joaquín, Vila, José M, Mauricio, María Dolores, Segarra, Gloria, Medina, Pascual, Martínez-León, Juan B, Lluch, Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adult Antithyroid Agents - therapeutic use Apamin - pharmacology Arteries - drug effects Arteries - physiopathology Biological and medical sciences Biological Factors - physiology Calcium - pharmacology Charybdotoxin - pharmacology Clinical Studies Endocrinopathies Endothelium, Vascular - physiopathology Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Humans Hyperthyroidism - drug therapy Hyperthyroidism - physiopathology Male Medical sciences Methimazole - therapeutic use Middle Aged Muscle Relaxation - drug effects Muscle, Smooth, Vascular - physiopathology Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Norepinephrine - pharmacology omega-N-Methylarginine - pharmacology Potassium - pharmacology Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - physiology Thyroid Gland - blood supply Vertebrates: endocrinology
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Zusammenfassung:	Objective: We studied the intervention of nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) in mediating responses to acetylcholine in thyroid arteries from euthyroid and methimazole-treated (MT) patients. Design and methods: Branches of the superior thyroid artery were obtained from 19 euthyroid patients and 17 MT patients (euthyroid at the time of surgery) undergoing total thyroidectomy or hemithyroidectomy. Artery rings were suspended in organ baths for isometric recording of tension. Results and conclusions: Acetylcholine caused endothelium-dependent relaxation of greater magnitude in arteries from MT patients (pD2 (−log EC50) values were 7.68±0.19 in euthyroid and 8.17±0.26 in MT patients, P
ISSN:	0804-4643 1479-683X
DOI:	10.1530/eje.1.01889