Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome

ObjectiveThe peroxisome proliferator-activated receptor (PPAR)γ is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARγ2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic...

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Veröffentlicht in:European journal of endocrinology 2009-08, Vol.161 (2), p.317-322
Hauptverfasser: Koika, Vasiliki, Marioli, Dimitra J, Saltamavros, Alexandros D, Vervita, Vasiliki, Koufogiannis, Kleanthis D, Adonakis, George, Decavalas, George, Georgopoulos, Neoklis A
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Sprache:eng
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Zusammenfassung:ObjectiveThe peroxisome proliferator-activated receptor (PPAR)γ is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARγ2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARγ2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.DesignCase–control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.MethodsHormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR–restriction fragment length polymorphism assay.ResultsGenotype frequencies of the Pro12Ala polymorphism in PPARγ2 did not differ among PCOS women and control subjects.The presence of Pro12Ala polymorphism of PPARγ2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI
ISSN:0804-4643
1479-683X
DOI:10.1530/EJE-08-1014