The Relationship Between Vitamin B12 and Gestational Diabetes in Pregnant Women With and Without Gestational Diabetes Mellitus

Objectives: Studies on the relationship between vitamin B12 and gestational diabetes mellitus (GDM) have shown different results. Given the lack of research in this area in Iran and the inconsistent findings of studies carried out in other nations, this study was conducted in light of the significance of the problem, particularly with regard to the health of expectant mothers. Materials and Methods: This case-control study was performed on 120 pregnant women referred to Ayatollah Rouhani hospital in Babol, private offices, and health centers to evaluate the vitamin B12 level in women with and without GDM. GDM was defined as 1) after oral ingestion of 75g glucose, fasting plasma glucose level (PGL) >92 mg/dL, 1-hour PGL >180mg/dL, or 2-hour PGL >153mg/ dL during 24-28 weeks of gestational age, or 2) in the 100-g oral glucose tolerance test (OGTT), PGL >195 mg/dL, one-hour PGL >180 mg/dL, 2-hour PGL >155, and 3-hour PGL >140, and GDM was diagnosed if there were at least 2 out of 4 mentioned cases. According to the above definition, pregnant women with GDM were placed in the case group, while those without GDM were placed in the control group. After 8 hours of fasting, intravenous blood samples were taken and sent to the laboratory for measurement, and vitamin B12 deficiency was considered 92. Conclusions: The results of the present study suggest that measuring vitamin B12 levels may aid in the early diagnosis of GDM and prevent maternal and fetal complications.