Small molecule inhibitors of IKK kinase activity

Small molecule inhibitors of IKK kinase activity

The nuclear transcription factor NF- B plays a significant role in the pathogenesis of a variety of diseases. Because of the key role played by the inhibitor of B kinase (IKK) complex in the activation of NF- B, coupled with the druggability of kinases as a target class, numerous companies have been...

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Veröffentlicht in:Expert opinion on therapeutic patents 2006-01, Vol.16 (1), p.1-12
Hauptverfasser: Coish, Philip DG, Wickens, Philip L, Lowinger, Timothy B
Format: Artikel
Sprache:eng
Schlagworte:
cancer
IKK-1
IKK-2
IKK-3
inflammation
IκB
NF-κB
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Zusammenfassung:The nuclear transcription factor NF- B plays a significant role in the pathogenesis of a variety of diseases. Because of the key role played by the inhibitor of B kinase (IKK) complex in the activation of NF- B, coupled with the druggability of kinases as a target class, numerous companies have been pursuing discovery programmes aimed at identifying small molecule inhibitors of these enzymes. This paper reviews the patenting activity associated with these efforts.
ISSN:1354-3776
1744-7674
DOI:10.1517/13543776.16.1.1