Noroudemansin A, a New Antifungal Antibiotic from Pterula Species 82168 and Three Semisynthetic Derivatives

A new antifungal (E)-β-methoxyacrylate, noroudemansin A (1), was isolated from cultures of Pterula sp. 82168. Its biological activities were investigated and compared with oudemansin A. The structure was elucidated by spectroscopic methods. Three semisynthetic noroudemansin A derivatives were synthe...

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Veröffentlicht in:	Zeitschrift für Naturforschung C. A journal of biosciences 1999-03, Vol.54 (3), p.163-168
Hauptverfasser:	Engler-Lohr, Michaela, Anke, Timm, Hellwig, Veronika, Steglich, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemistry Acrylates - isolation & purification Acrylates - pharmacology Animals Antibiotics Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - toxicity Antifungal Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Basidiomycetes Basidiomycota Cell Line Cell Survival - drug effects Cricetinae Fungi - drug effects HeLa Cells HL-60 Cells - drug effects Humans Leukemia L1210 Mice Microbial Sensitivity Tests Molecular Structure Noroudemansin A Penicillium - drug effects Structure-Activity Relationship Tumor Cells, Cultured
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Zusammenfassung:	A new antifungal (E)-β-methoxyacrylate, noroudemansin A (1), was isolated from cultures of Pterula sp. 82168. Its biological activities were investigated and compared with oudemansin A. The structure was elucidated by spectroscopic methods. Three semisynthetic noroudemansin A derivatives were synthesized from the natural product.
ISSN:	0939-5075 1865-7125
DOI:	10.1515/znc-1999-3-404