(+)-10α-Hydroxy-4-muurolen-3-one, a New Inhibitor of Leukotriene Biosynthesis from a Favolaschia Species. Comparison with Other Sesquiterpenes

(+)-10α-Hydroxy-4-muurolen-3-one, a New Inhibitor of Leukotriene Biosynthesis from a Favolaschia Species. Comparison with Other Sesquiterpenes

A new inhibitor of leukotriene biosynthesis, (+)-10α-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosy...

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Veröffentlicht in:Zeitschrift für Naturforschung C. A journal of biosciences 1996-08, Vol.51 (7), p.487-492
Hauptverfasser: Zapf, Sylvia, Wunder, Annette, Anke, Timm, Klostermeyer, Dörte, Steglich, Wolfgang, Shan, Rudong, Sterner, Olov, Scheuer, Werner
Format: Artikel
Sprache:eng
Schlagworte:
(+)-10α-Hydroxy-4-muurolen-3-one
Basidiomycetes
Favolaschia Species
Leukotriene Biosynthesis-Inhibitors
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Zusammenfassung:A new inhibitor of leukotriene biosynthesis, (+)-10α-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3a-hydroxy-T-cadinol, three related sesquiterpenes.
ISSN:0939-5075
1865-7125
DOI:10.1515/znc-1996-7-806