Fusapyridons A and B, Novel Pyridone Alkaloids from an Endophytic Fungus, Fusarium sp. YG-45

Fusapyridons A and B, Novel Pyridone Alkaloids from an Endophytic Fungus, Fusarium sp. YG-45

Through our screening for new natural compounds, two 3,4,5-trisubstituted N-methyl-2-pyridone alkaloids, fusapyridons A (1) and B (2), along with the known compounds sambutoxin (3), Ndemethylsambutoxin (4), (-)-oxysporidinone (5), and the dimethyl ketal of oxysporidinone (6) were isolated from the f...

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Veröffentlicht in:Zeitschrift für Naturforschung. B, A journal of chemical sciences A journal of chemical sciences, 2007-09, Vol.62 (9), p.1203-1207
Hauptverfasser: Tsuchinari, Mio, Shimanuki, Keiko, Hiramatsu, Fuminori, Murayama, Tetsuya, Koseki, Takuya, Shiono, Yoshihito
Format: Artikel
Sprache:eng
Schlagworte:
Endophyte
Fusapyridons A and B
Fusarium sp
Pyridone
Sambutoxin
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Zusammenfassung:Through our screening for new natural compounds, two 3,4,5-trisubstituted N-methyl-2-pyridone alkaloids, fusapyridons A (1) and B (2), along with the known compounds sambutoxin (3), Ndemethylsambutoxin (4), (-)-oxysporidinone (5), and the dimethyl ketal of oxysporidinone (6) were isolated from the fermentation extract of Fusarium sp. YG-45. Their structures were determined by spectroscopic analyses including NMR, MS, UV and IR. Compound 1 showed antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
ISSN:0932-0776
1865-7117
DOI:10.1515/znb-2007-0916