Biotransformation of Jatrophone by Aspergillus niger ATCC 16404
Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compo...
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| Veröffentlicht in: | Zeitschrift für Naturforschung. B, A journal of chemical sciences A journal of chemical sciences, 2007-02, Vol.62 (2), p.275-279 |
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| container_issue | 2 |
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| container_title | Zeitschrift für Naturforschung. B, A journal of chemical sciences |
| container_volume | 62 |
| creator | Pertino, Mariano Schmeda-Hirschmann, Guillermo Santos, Leonardo S. Rodríguez, Jaime A. Theoduloz, Cristina |
| description | Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC
values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compound 1 and 53.1 and 260 μM for 2, respectively. Microbial transformation of 1 into compound 2 strongly reduced the cytotoxicity and enhanced the selectivity against AGS cells. |
| doi_str_mv | 10.1515/znb-2007-0221 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0932-0776 |
| ispartof | Zeitschrift für Naturforschung. B, A journal of chemical sciences, 2007-02, Vol.62 (2), p.275-279 |
| issn | 0932-0776 1865-7117 |
| language | eng |
| recordid | cdi_crossref_primary_10_1515_znb_2007_0221 |
| source | Alma/SFX Local Collection |
| subjects | Aspergillus niger Biotransformation Jatrophone |
| title | Biotransformation of Jatrophone by Aspergillus niger ATCC 16404 |
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