Biotransformation of Jatrophone by Aspergillus niger ATCC 16404

Biotransformation of Jatrophone by Aspergillus niger ATCC 16404

Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compo...

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Veröffentlicht in:Zeitschrift für Naturforschung. B, A journal of chemical sciences A journal of chemical sciences, 2007-02, Vol.62 (2), p.275-279
Hauptverfasser: Pertino, Mariano, Schmeda-Hirschmann, Guillermo, Santos, Leonardo S., Rodríguez, Jaime A., Theoduloz, Cristina
Format: Artikel
Sprache:eng
Schlagworte:
Aspergillus niger
Biotransformation
Jatrophone
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Zusammenfassung:Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compound 1 and 53.1 and 260 μM for 2, respectively. Microbial transformation of 1 into compound 2 strongly reduced the cytotoxicity and enhanced the selectivity against AGS cells.
ISSN:0932-0776
1865-7117
DOI:10.1515/znb-2007-0221