Functionalized SWCNTs@Ag–TiO 2 nanocomposites induce ROS-mediated apoptosis and autophagy in liver cancer cells
Hybrid nanomaterials with unique physiochemical properties have received a lot of attention, making them attractive for application in different fields like cancer treatment. This study was designed to investigate the combined effects of single-walled carbon nanotubes (SWCNTs) hybridized with silver...
Gespeichert in:
Veröffentlicht in: | Nanotechnology reviews (Berlin) 2023-10, Vol.12 (1) |
---|---|
Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Hybrid nanomaterials with unique physiochemical properties have received a lot of attention, making them attractive for application in different fields like cancer treatment. This study was designed to investigate the combined effects of single-walled carbon nanotubes (SWCNTs) hybridized with silver titanium dioxide composite (SWCNTs@Ag–TiO
2
). Transmission electron microscopy and field emission scanning electron microscopy images demonstrated the accumulation of SWCNTs with Ag–TiO
2
due to an increased main grain size with functionalization to 40 nm. The D and G bands in SWCNTs @Ag–TiO
2
shifted to 1,366 and 1,534 cm
−1
, respectively. SWCNTs@Ag-TiO
2
were assessed for their cytotoxicity and autophagy induction in liver cancer cells (Hep-G2) using the lactate dehydrogenase assay, MTT assay, and flow cytometry methods. The results showed that SWCNTs and SWCNTs@Ag–TiO
2
exhibited strong anti-cancer activity
in vitro
against Hep-G2 cells by inducing apoptosis and autophagy in liver cancer cells
via
controlling the AKT and JNK mitogen-activated protein kinase pathways. The results show that SWCNTs and SWCNTs coated with silver/titanium dioxide (SWCNTs@Ag–TiO
2
) reduce the cells’ viability and proliferation. It was shown that an excessive amount of reactive oxygen species was a crucial mediator of both the cell death caused by SWCNTs and the cell death caused by SWCNTs combined with Ag–TiO
2
. Based on these findings, it appears that SWCNTs and SWCNTs@Ag–TiO
2
have the potential to be developed as nanotherapeutics for the treatment of liver cancer cells. |
---|---|
ISSN: | 2191-9097 2191-9097 |
DOI: | 10.1515/ntrev-2023-0127 |