Death domain associated protein (Daxx), a multi-functional protein

Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell survival and apoptosis remain largely obscure. Our review of rec...

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Veröffentlicht in:Cellular & molecular biology letters 2015-12, Vol.20 (5), p.788-797
Hauptverfasser: Tang, Shuang-Yang, Wan, Yan-Ping, Wu, Yi-Mou
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Wan, Yan-Ping
Wu, Yi-Mou
description Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell survival and apoptosis remain largely obscure. Our review of recent studies shows that Daxx has many interesting functional dualities and can provide a reference for further research on Daxx.
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subjects Adaptor Proteins, Signal Transducing - chemistry
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Apoptosis
Chromatin - metabolism
Death domain associated protein
DNA Helicases - chemistry
DNA Helicases - metabolism
Expression
Function
Humans
Interaction
Localization
Modification
Mutation
Neoplasms - metabolism
Neoplasms - pathology
Nuclear Proteins - chemistry
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Regulation
Small Ubiquitin-Related Modifier Proteins - metabolism
Telomerase - metabolism
Transcription
X-linked Nuclear Protein
title Death domain associated protein (Daxx), a multi-functional protein
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