Death domain associated protein (Daxx), a multi-functional protein

Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell survival and apoptosis remain largely obscure. Our review of rec...

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Veröffentlicht in:	Cellular & molecular biology letters 2015-12, Vol.20 (5), p.788-797
Hauptverfasser:	Tang, Shuang-Yang, Wan, Yan-Ping, Wu, Yi-Mou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Chromatin - metabolism Death domain associated protein DNA Helicases - chemistry DNA Helicases - metabolism Expression Function Humans Interaction Localization Modification Mutation Neoplasms - metabolism Neoplasms - pathology Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Regulation Small Ubiquitin-Related Modifier Proteins - metabolism Telomerase - metabolism Transcription X-linked Nuclear Protein
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Zusammenfassung:	Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell survival and apoptosis remain largely obscure. Our review of recent studies shows that Daxx has many interesting functional dualities and can provide a reference for further research on Daxx.
ISSN:	1689-1392 1689-1392
DOI:	10.1515/cmble-2015-0048