Fetal brain injury in experimental intrauterine asphyxia and inflammation in Göttingen minipigs

Objective: To examine fetal brain injury in the Göttingen minipig following intrauterine asphyxia and infection/inflammation induced at 3/4 of gestational length. Methods: We performed laparotomy after anesthesia in six pregnant sows. We randomized 29 fetuses to one of four groups: pretreatment with...

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Veröffentlicht in:	Journal of perinatal medicine 2006-05, Vol.34 (3), p.226-234
Hauptverfasser:	Lyng, Kristin, Munkeby, Berit H., Scheie, David, Mallard, Carina, Hagberg, Henrik, Stray-Pedersen, Babill, Saugstad, Ola Didrik, Frøen, J. Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asphyxia - pathology Biological and medical sciences Brain - embryology Brain - pathology Delivery. Postpartum. Lactation Disease Models, Animal Endotoxins - toxicity Female Fetal brain injury Fetal Diseases - pathology Fetal Weight Gynecology. Andrology. Obstetrics inflammation Inflammation - metabolism Inflammation - pathology intrauterine asphyxia Medical sciences Microglia - pathology Necrosis Neurons - pathology pigs Pregnancy Swine Swine, Miniature Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Objective: To examine fetal brain injury in the Göttingen minipig following intrauterine asphyxia and infection/inflammation induced at 3/4 of gestational length. Methods: We performed laparotomy after anesthesia in six pregnant sows. We randomized 29 fetuses to one of four groups: pretreatment with saline or endotoxin followed by 30 min of umbilical cord occlusion or no occlusion. After 48 h we performed a re-laparotomy and examined the fetal brains. Results: After total asphyxia, brain stem injury was present in the group pretreated with saline (P
ISSN:	0300-5577 1619-3997
DOI:	10.1515/JPM.2006.041