Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes
The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whet...
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| Veröffentlicht in: | Endocrine Journal 2006, Vol.53(5), pp.665-670 |
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| container_title | Endocrine Journal |
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| creator | IKEDA, Yukio SUEHIRO, Tadashi YAMANAKA, Shigeo KUMON, Yoshitaka TAKATA, Hiroshi INADA, Shojiro OGAMI, Naoko OSAKI, Fumiaki INOUE, Mari ARII, Kaoru HASHIMOTO, Kozo |
| description | The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron status was associated with circulating oxidized LDL (oxLDL) levels in type 2 diabetic patients, in whom oxidative stress and susceptibility to lipid oxidation were supposedly increased. Serum ferritin levels were significantly correlated with plasma oxLDL concentrations in both male and female patients (p |
| doi_str_mv | 10.1507/endocrj.K06-010 |
| format | Article |
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Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron status was associated with circulating oxidized LDL (oxLDL) levels in type 2 diabetic patients, in whom oxidative stress and susceptibility to lipid oxidation were supposedly increased. Serum ferritin levels were significantly correlated with plasma oxLDL concentrations in both male and female patients (p<0.02 and p<0.05, respectively). No correlation was detected between ferritin and LDL-cholesterol (LDL-C) concentrations despite the close correlation between LDL-C and oxLDL concentrations (p<0.0001). Stepwise regression analysis showed that ferritin concentration was an independent positive determinant of oxLDL level, in addition to triglyceride concentration, body mass index and sex. This is the first report to show that serum ferritin is associated with circulating oxLDL levels in patients with type 2 diabetes. Further work is required to establish a causative link between iron excess and the development of diabetic vascular complications.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.K06-010</identifier><identifier>PMID: 16902260</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Aged ; Biomarkers - blood ; Body Mass Index ; Cholesterol, LDL - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Ferritin ; Ferritins - blood ; Humans ; Iron ; Lipid Peroxidation ; Lipoproteins, LDL - blood ; Male ; Middle Aged ; Oxidized LDL ; Regression Analysis ; Sex Characteristics ; Type 2 diabetes</subject><ispartof>Endocrine Journal, 2006, Vol.53(5), pp.665-670</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-7af791a10a3b04309dec4226a7a04bdfcd62c037620450ee072a4cd70b5ea8773</citedby><cites>FETCH-LOGICAL-c532t-7af791a10a3b04309dec4226a7a04bdfcd62c037620450ee072a4cd70b5ea8773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16902260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IKEDA, Yukio</creatorcontrib><creatorcontrib>SUEHIRO, Tadashi</creatorcontrib><creatorcontrib>YAMANAKA, Shigeo</creatorcontrib><creatorcontrib>KUMON, Yoshitaka</creatorcontrib><creatorcontrib>TAKATA, Hiroshi</creatorcontrib><creatorcontrib>INADA, Shojiro</creatorcontrib><creatorcontrib>OGAMI, Naoko</creatorcontrib><creatorcontrib>OSAKI, Fumiaki</creatorcontrib><creatorcontrib>INOUE, Mari</creatorcontrib><creatorcontrib>ARII, Kaoru</creatorcontrib><creatorcontrib>HASHIMOTO, Kozo</creatorcontrib><title>Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes</title><title>Endocrine Journal</title><addtitle>Endocr J</addtitle><description>The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron status was associated with circulating oxidized LDL (oxLDL) levels in type 2 diabetic patients, in whom oxidative stress and susceptibility to lipid oxidation were supposedly increased. Serum ferritin levels were significantly correlated with plasma oxLDL concentrations in both male and female patients (p<0.02 and p<0.05, respectively). No correlation was detected between ferritin and LDL-cholesterol (LDL-C) concentrations despite the close correlation between LDL-C and oxLDL concentrations (p<0.0001). Stepwise regression analysis showed that ferritin concentration was an independent positive determinant of oxLDL level, in addition to triglyceride concentration, body mass index and sex. This is the first report to show that serum ferritin is associated with circulating oxLDL levels in patients with type 2 diabetes. Further work is required to establish a causative link between iron excess and the development of diabetic vascular complications.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - blood</subject><subject>Humans</subject><subject>Iron</subject><subject>Lipid Peroxidation</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidized LDL</subject><subject>Regression Analysis</subject><subject>Sex Characteristics</subject><subject>Type 2 diabetes</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNFOwyAUhonR6Jxee2d4geqhQFkvzXRqbKKJ87qhcKYsW9sAc05fXsyWeQMkfP9_Tj5CLhhcMQnqGlvbGT-_eoIiAwYHZMC4GGVCCjgkAyjZKBuVsjwhpyHMATiXgh-TE1aUkOcFDMjPTQidcTq6rqUNxjViS1_Rr5Z0gt676FqqW0vHzpvVImHtO33-ctZ9o6VVt84stsHFDa1c3_W-i5gCFX7iItD0ekkJbGOgaxc_6HTTI83prdNpEoYzcjTTi4Dnu3tI3iZ30_FDVj3fP45vqsxInsdM6ZkqmWageQOCQ2nRiLS9VhpEY2fGFrkBroochAREULkWxipoJOqRUnxIrre9xncheJzVvXdL7Tc1g_pPY73TWCeNddKYEpfbRL9qlmj_-Z23BIy3wDxE_Y57QPvozAL3hZLXcnsUhdz_mg_tE8J_ASNPin4</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>IKEDA, Yukio</creator><creator>SUEHIRO, Tadashi</creator><creator>YAMANAKA, Shigeo</creator><creator>KUMON, Yoshitaka</creator><creator>TAKATA, Hiroshi</creator><creator>INADA, Shojiro</creator><creator>OGAMI, Naoko</creator><creator>OSAKI, Fumiaki</creator><creator>INOUE, Mari</creator><creator>ARII, Kaoru</creator><creator>HASHIMOTO, Kozo</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2006</creationdate><title>Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes</title><author>IKEDA, Yukio ; SUEHIRO, Tadashi ; YAMANAKA, Shigeo ; KUMON, Yoshitaka ; TAKATA, Hiroshi ; INADA, Shojiro ; OGAMI, Naoko ; OSAKI, Fumiaki ; INOUE, Mari ; ARII, Kaoru ; HASHIMOTO, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-7af791a10a3b04309dec4226a7a04bdfcd62c037620450ee072a4cd70b5ea8773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Cholesterol, LDL - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Humans</topic><topic>Iron</topic><topic>Lipid Peroxidation</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidized LDL</topic><topic>Regression Analysis</topic><topic>Sex Characteristics</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IKEDA, Yukio</creatorcontrib><creatorcontrib>SUEHIRO, Tadashi</creatorcontrib><creatorcontrib>YAMANAKA, Shigeo</creatorcontrib><creatorcontrib>KUMON, Yoshitaka</creatorcontrib><creatorcontrib>TAKATA, Hiroshi</creatorcontrib><creatorcontrib>INADA, Shojiro</creatorcontrib><creatorcontrib>OGAMI, Naoko</creatorcontrib><creatorcontrib>OSAKI, Fumiaki</creatorcontrib><creatorcontrib>INOUE, Mari</creatorcontrib><creatorcontrib>ARII, Kaoru</creatorcontrib><creatorcontrib>HASHIMOTO, Kozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKEDA, Yukio</au><au>SUEHIRO, Tadashi</au><au>YAMANAKA, Shigeo</au><au>KUMON, Yoshitaka</au><au>TAKATA, Hiroshi</au><au>INADA, Shojiro</au><au>OGAMI, Naoko</au><au>OSAKI, Fumiaki</au><au>INOUE, Mari</au><au>ARII, Kaoru</au><au>HASHIMOTO, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2006</date><risdate>2006</risdate><volume>53</volume><issue>5</issue><spage>665</spage><epage>670</epage><pages>665-670</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron status was associated with circulating oxidized LDL (oxLDL) levels in type 2 diabetic patients, in whom oxidative stress and susceptibility to lipid oxidation were supposedly increased. Serum ferritin levels were significantly correlated with plasma oxLDL concentrations in both male and female patients (p<0.02 and p<0.05, respectively). No correlation was detected between ferritin and LDL-cholesterol (LDL-C) concentrations despite the close correlation between LDL-C and oxLDL concentrations (p<0.0001). Stepwise regression analysis showed that ferritin concentration was an independent positive determinant of oxLDL level, in addition to triglyceride concentration, body mass index and sex. This is the first report to show that serum ferritin is associated with circulating oxLDL levels in patients with type 2 diabetes. Further work is required to establish a causative link between iron excess and the development of diabetic vascular complications.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>16902260</pmid><doi>10.1507/endocrj.K06-010</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers - blood Body Mass Index Cholesterol, LDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Female Ferritin Ferritins - blood Humans Iron Lipid Peroxidation Lipoproteins, LDL - blood Male Middle Aged Oxidized LDL Regression Analysis Sex Characteristics Type 2 diabetes |
| title | Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes |
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