Association between Serum Ferritin and Circulating Oxidized Low-density Lipoprotein Levels in Patients with Type 2 Diabetes

The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whet...

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Veröffentlicht in:	Endocrine Journal 2006, Vol.53(5), pp.665-670
Hauptverfasser:	IKEDA, Yukio, SUEHIRO, Tadashi, YAMANAKA, Shigeo, KUMON, Yoshitaka, TAKATA, Hiroshi, INADA, Shojiro, OGAMI, Naoko, OSAKI, Fumiaki, INOUE, Mari, ARII, Kaoru, HASHIMOTO, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood Body Mass Index Cholesterol, LDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Female Ferritin Ferritins - blood Humans Iron Lipid Peroxidation Lipoproteins, LDL - blood Male Middle Aged Oxidized LDL Regression Analysis Sex Characteristics Type 2 diabetes
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Zusammenfassung:	The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron status was associated with circulating oxidized LDL (oxLDL) levels in type 2 diabetic patients, in whom oxidative stress and susceptibility to lipid oxidation were supposedly increased. Serum ferritin levels were significantly correlated with plasma oxLDL concentrations in both male and female patients (p
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.K06-010