Serotonin receptor-mediated vasorelaxation occurs primarily through 5-HT 4 activation in bovine lateral saphenous vein

To better understand mechanisms of serotonin- (5-HT) mediated vasorelaxation, isolated lateral saphenous veins from cattle were assessed for vasoactivity using myography in response to increasing concentrations of 5-HT or selective 5-HT receptor agonists. Vessels were pre-contracted with 1 × 10 M p...

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Veröffentlicht in:	Physiological reports 2024-07, Vol.12 (13), p.e16128
Hauptverfasser:	Trotta, Ronald J, Harmon, David L, Klotz, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Male Phenylephrine - pharmacology Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT4 - metabolism Saphenous Vein - drug effects Saphenous Vein - metabolism Saphenous Vein - physiology Serotonin - pharmacology Serotonin Receptor Agonists - pharmacology Vasodilation - drug effects Vasodilation - physiology
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Zusammenfassung:	To better understand mechanisms of serotonin- (5-HT) mediated vasorelaxation, isolated lateral saphenous veins from cattle were assessed for vasoactivity using myography in response to increasing concentrations of 5-HT or selective 5-HT receptor agonists. Vessels were pre-contracted with 1 × 10 M phenylephrine and exposed to increasing concentrations of 5-HT or 5-HT receptor agonists that were selective for 5-HT , 5-HT , 5-HT , and 5-HT . Vasoactive response data were normalized as a percentage of the maximum contractile response induced by the phenylephrine pre-contraction. At 1 × 10 M 5-HT, a relaxation was observed with an 88.7% decrease (p
ISSN:	2051-817X
DOI:	10.14814/phy2.16128