Altered chemosensitivity to CO 2 during exercise
The effect of exercise on chemosensitivity to carbon dioxide (CO ) has been controversial. Most studies have been based on rebreathing to alter inspired CO which is poorly tolerated in exercise. Instead, inhaling a fixed 3% CO from rest to moderate exercise was found to be well tolerated by seven no...
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| Veröffentlicht in: | Physiological reports 2021-06, Vol.9 (11), p.e14882 |
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| creator | Yamashiro, Stanley M Kato, Takahide Matsumoto, Takaaki |
| description | The effect of exercise on chemosensitivity to carbon dioxide (CO
) has been controversial. Most studies have been based on rebreathing to alter inspired CO
which is poorly tolerated in exercise. Instead, inhaling a fixed 3% CO
from rest to moderate exercise was found to be well tolerated by seven normal subjects enabling CO
chemosensitivity to be studied with minimal negative reaction. Results showed that chemosensitivity to CO
following 5-6 min of stimulation was significantly enhanced during mild exercise (p |
| doi_str_mv | 10.14814/phy2.14882 |
| format | Article |
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) has been controversial. Most studies have been based on rebreathing to alter inspired CO
which is poorly tolerated in exercise. Instead, inhaling a fixed 3% CO
from rest to moderate exercise was found to be well tolerated by seven normal subjects enabling CO
chemosensitivity to be studied with minimal negative reaction. Results showed that chemosensitivity to CO
following 5-6 min of stimulation was significantly enhanced during mild exercise (p < 0.01). This motivated exploring how much of the dynamic ventilatory response to mild exercise breathing air could be predicted by a model with central and peripheral chemosensitivity. Chemoreceptor stimulation combined with hypercapnia has been associated with long-term facilitation of ventilation (LTF). 3% CO
inhalation during moderate exercise led to ventilation augmentation consistent with LTF following 6 min of exercise in seven normal human subjects (p < 0.01). Increased ventilation could not be attributed to hypercapnia or metabolic changes. Moderate exercise breathing air resulted in significantly less augmentation. In conclusion, both peripheral and central chemosensitivity to CO
increased in exercise with the peripheral chemoreceptors playing a dominant role. This separation of central and peripheral contributions was not previously reported. This chemoreceptor stimulation can lead to augmented ventilation consistent with LTF.</description><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.14882</identifier><identifier>PMID: 34110716</identifier><language>eng</language><publisher>United States</publisher><subject>Carbon Dioxide - pharmacology ; Chemoreceptor Cells - drug effects ; Exercise - physiology ; Humans ; Hypercapnia - metabolism ; Hypercapnia - physiopathology ; Male ; Respiration - drug effects ; Young Adult</subject><ispartof>Physiological reports, 2021-06, Vol.9 (11), p.e14882</ispartof><rights>2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1382-d3a0542c4a8e8fcec72062dbd1a42b79a8e48f422ed53d6568482e79fb45fe353</citedby><cites>FETCH-LOGICAL-c1382-d3a0542c4a8e8fcec72062dbd1a42b79a8e48f422ed53d6568482e79fb45fe353</cites><orcidid>0000-0001-6690-430X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34110716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamashiro, Stanley M</creatorcontrib><creatorcontrib>Kato, Takahide</creatorcontrib><creatorcontrib>Matsumoto, Takaaki</creatorcontrib><title>Altered chemosensitivity to CO 2 during exercise</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>The effect of exercise on chemosensitivity to carbon dioxide (CO
) has been controversial. Most studies have been based on rebreathing to alter inspired CO
which is poorly tolerated in exercise. Instead, inhaling a fixed 3% CO
from rest to moderate exercise was found to be well tolerated by seven normal subjects enabling CO
chemosensitivity to be studied with minimal negative reaction. Results showed that chemosensitivity to CO
following 5-6 min of stimulation was significantly enhanced during mild exercise (p < 0.01). This motivated exploring how much of the dynamic ventilatory response to mild exercise breathing air could be predicted by a model with central and peripheral chemosensitivity. Chemoreceptor stimulation combined with hypercapnia has been associated with long-term facilitation of ventilation (LTF). 3% CO
inhalation during moderate exercise led to ventilation augmentation consistent with LTF following 6 min of exercise in seven normal human subjects (p < 0.01). Increased ventilation could not be attributed to hypercapnia or metabolic changes. Moderate exercise breathing air resulted in significantly less augmentation. In conclusion, both peripheral and central chemosensitivity to CO
increased in exercise with the peripheral chemoreceptors playing a dominant role. This separation of central and peripheral contributions was not previously reported. This chemoreceptor stimulation can lead to augmented ventilation consistent with LTF.</description><subject>Carbon Dioxide - pharmacology</subject><subject>Chemoreceptor Cells - drug effects</subject><subject>Exercise - physiology</subject><subject>Humans</subject><subject>Hypercapnia - metabolism</subject><subject>Hypercapnia - physiopathology</subject><subject>Male</subject><subject>Respiration - drug effects</subject><subject>Young Adult</subject><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j99LwzAUhYMgbsw9-S59l-rNTdKmj6OoEwZ7UfCttMmNi6xrSTqx_737oT6dw-HjwMfYDYd7LjWXD_1mxGPVeMGmCIqnmufvEzaP8RMAOAhRgLxiEyE5h5xnUwaL7UCBbGI21HaRdtEP_ssPYzJ0SblOMLH74HcfCX1TMD7SNbt09TbS_Ddn7O3p8bVcpqv180u5WKWGC42pFTUoiUbWmrQzZHKEDG1jeS2xyYvDLLWTiGSVsJnKtNRIeeEaqRwJJWbs7vxrQhdjIFf1wbd1GCsO1Um3OupWJ90DfXum-33Tkv1n_0TFD4hJUUQ</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Yamashiro, Stanley M</creator><creator>Kato, Takahide</creator><creator>Matsumoto, Takaaki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-6690-430X</orcidid></search><sort><creationdate>202106</creationdate><title>Altered chemosensitivity to CO 2 during exercise</title><author>Yamashiro, Stanley M ; Kato, Takahide ; Matsumoto, Takaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1382-d3a0542c4a8e8fcec72062dbd1a42b79a8e48f422ed53d6568482e79fb45fe353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carbon Dioxide - pharmacology</topic><topic>Chemoreceptor Cells - drug effects</topic><topic>Exercise - physiology</topic><topic>Humans</topic><topic>Hypercapnia - metabolism</topic><topic>Hypercapnia - physiopathology</topic><topic>Male</topic><topic>Respiration - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamashiro, Stanley M</creatorcontrib><creatorcontrib>Kato, Takahide</creatorcontrib><creatorcontrib>Matsumoto, Takaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamashiro, Stanley M</au><au>Kato, Takahide</au><au>Matsumoto, Takaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered chemosensitivity to CO 2 during exercise</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2021-06</date><risdate>2021</risdate><volume>9</volume><issue>11</issue><spage>e14882</spage><pages>e14882-</pages><eissn>2051-817X</eissn><abstract>The effect of exercise on chemosensitivity to carbon dioxide (CO
) has been controversial. Most studies have been based on rebreathing to alter inspired CO
which is poorly tolerated in exercise. Instead, inhaling a fixed 3% CO
from rest to moderate exercise was found to be well tolerated by seven normal subjects enabling CO
chemosensitivity to be studied with minimal negative reaction. Results showed that chemosensitivity to CO
following 5-6 min of stimulation was significantly enhanced during mild exercise (p < 0.01). This motivated exploring how much of the dynamic ventilatory response to mild exercise breathing air could be predicted by a model with central and peripheral chemosensitivity. Chemoreceptor stimulation combined with hypercapnia has been associated with long-term facilitation of ventilation (LTF). 3% CO
inhalation during moderate exercise led to ventilation augmentation consistent with LTF following 6 min of exercise in seven normal human subjects (p < 0.01). Increased ventilation could not be attributed to hypercapnia or metabolic changes. Moderate exercise breathing air resulted in significantly less augmentation. In conclusion, both peripheral and central chemosensitivity to CO
increased in exercise with the peripheral chemoreceptors playing a dominant role. This separation of central and peripheral contributions was not previously reported. This chemoreceptor stimulation can lead to augmented ventilation consistent with LTF.</abstract><cop>United States</cop><pmid>34110716</pmid><doi>10.14814/phy2.14882</doi><orcidid>https://orcid.org/0000-0001-6690-430X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiological reports, 2021-06, Vol.9 (11), p.e14882 |
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| language | eng |
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| source | MEDLINE; Wiley-Blackwell Open Access Titles; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Carbon Dioxide - pharmacology Chemoreceptor Cells - drug effects Exercise - physiology Humans Hypercapnia - metabolism Hypercapnia - physiopathology Male Respiration - drug effects Young Adult |
| title | Altered chemosensitivity to CO 2 during exercise |
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