C-H Functionalization and C-N Bond Formation Approaches under Catalytic Conditions for the Synthesis of α-Ketoamides and 2,4-Disubstituted-1,3,5-triazines
This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(...
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Veröffentlicht in: | Asian journal of chemistry 2022-07, Vol.34 (7), p.1841-1847 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | This work describes an easy way to perform approach for the transformation of arylmethyl ketones to
α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in
water under peroxide free reaction conditions. The established amidation reaction proceeds via
α-C(sp3)-H functionalization and C-N bond formation approaches in water at ambient temperature.
On the other hand, a novel and straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via
nickel-catalyzed cyclization of amidines with DMSO as one-carbon synthon has been developed. The
developed strategy proceeds via C-N bond formation. |
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ISSN: | 0970-7077 0975-427X |
DOI: | 10.14233/ajchem.2022.23769 |