C-H Functionalization and C-N Bond Formation Approaches under Catalytic Conditions for the Synthesis of α-Ketoamides and 2,4-Disubstituted-1,3,5-triazines

This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(...

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Veröffentlicht in:Asian journal of chemistry 2022-07, Vol.34 (7), p.1841-1847
Hauptverfasser: Singh, Laimujam Sidartha, Kabi, Arup K., Sengupta, Ragini, Roy, Anupam, Sahoo, Abhishek, Saha, Indranil, Malakar, Chandi C.
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Sprache:eng
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Zusammenfassung:This work describes an easy way to perform approach for the transformation of arylmethyl ketones to α-ketoamides using secondary amines as starting materials in the presence of iodine as a catalyst in water under peroxide free reaction conditions. The established amidation reaction proceeds via α-C(sp3)-H functionalization and C-N bond formation approaches in water at ambient temperature. On the other hand, a novel and straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via nickel-catalyzed cyclization of amidines with DMSO as one-carbon synthon has been developed. The developed strategy proceeds via C-N bond formation.
ISSN:0970-7077
0975-427X
DOI:10.14233/ajchem.2022.23769