Synthesis and Antimicrobial Activity of Piperine Analogues Containing 1,2,4-Triazole Ring

Synthesis and Antimicrobial Activity of Piperine Analogues Containing 1,2,4-Triazole Ring

A series 1,2,4-triazole piperine analogues (TP1-TP6) were designed and synthesized. The structures were confirmed using 1H NMR and 13C NMR. Antibacterial study was done using Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative micro-organisms (E. coli and Pseudomonas aerugino...

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Veröffentlicht in:Asian journal of chemistry 2019-04, Vol.31 (5), p.1077-1080
Hauptverfasser: Kumar, Kottakki Naveen, Amperayani, Karteek Rao, Sankar Ummdi, V. Ravi, Parimi, Uma Devi
Format: Artikel
Sprache:eng
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Zusammenfassung:A series 1,2,4-triazole piperine analogues (TP1-TP6) were designed and synthesized. The structures were confirmed using 1H NMR and 13C NMR. Antibacterial study was done using Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative micro-organisms (E. coli and Pseudomonas aeruginosa) by disc diffusion method. Compound containing chloro substitution (TP6) showed the highest effect, while compound TP1, TP3, TP4, TP5 showed the moderate activity.
ISSN:0970-7077
0975-427X
DOI:10.14233/ajchem.2019.21876