A Placebo-controlled Dose-finding Study With Bambuterol in Elderly Patients With Asthma

A new long-acting bronchodilator prodrug, bambuterol hydrochloride, was tested in a randomized, crossover, and double-blind study in elderly asthmatic patients (aged 64 to 82 years). They received placebo and 5-mg, 10-mg, and 20-mg tablets once daily for a week at each dose. The plasma concentration...

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Veröffentlicht in:	Chest 1993-03, Vol.103 (3), p.771-776
Hauptverfasser:	Sitar, Daniel S., Aoki, Fred Y., Warren, Charles P., Knight, Allan, Grossman, Ronald F., Alexander, Michael, Soliman, Sherif
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Asthma - blood Asthma - drug therapy Asthma - physiopathology Biological and medical sciences Bronchodilator Agents - administration & dosage Bronchodilator Agents - adverse effects Cholinesterases - blood Cholinesterases - drug effects Delayed-Action Preparations Dose-Response Relationship, Drug Double-Blind Method Female Forced Expiratory Volume - drug effects Humans Male Medical sciences Peak Expiratory Flow Rate - drug effects Pharmacology. Drug treatments Placebos Prodrugs - administration & dosage Prodrugs - adverse effects Respiratory system Terbutaline - administration & dosage Terbutaline - adverse effects Terbutaline - analogs & derivatives Terbutaline - blood
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Beschreibung
Zusammenfassung:	A new long-acting bronchodilator prodrug, bambuterol hydrochloride, was tested in a randomized, crossover, and double-blind study in elderly asthmatic patients (aged 64 to 82 years). They received placebo and 5-mg, 10-mg, and 20-mg tablets once daily for a week at each dose. The plasma concentration of the active metabolite, terbutaline, increased linearly with the dose of drug (p
ISSN:	0012-3692 1931-3543
DOI:	10.1378/chest.103.3.771