Evaluation of a TLC Densitometric Method for Analysis of Azole Antifungal Agents

A new method for identification and quantitative determination of the azole antifungal agents; ketoconazole, bifonazole, fluconazole and itraconazole is described using TLC with densitometric detection. Validation of the method was carried out to confirm its precision (%RSD ranged between 1.31 and 3...

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Veröffentlicht in:	Chromatographia 2008-06, Vol.67 (11-12), p.995-998
Hauptverfasser:	Ekiert, Radosław J, Krzek, Jan, Rzeszutko, Włodzimierz
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical Chemistry Biological and medical sciences Chemistry Chemistry and Materials Science Chromatography Full Short Communication General pharmacology Laboratory Medicine Medical sciences Pharmacology. Drug treatments Pharmacy Proteomics
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Beschreibung
Zusammenfassung:	A new method for identification and quantitative determination of the azole antifungal agents; ketoconazole, bifonazole, fluconazole and itraconazole is described using TLC with densitometric detection. Validation of the method was carried out to confirm its precision (%RSD ranged between 1.31 and 3.45), recovery (99.7-102.4%) and linearity (r = 0.99287-0.99722) within the concentration range under investigation. The experimental conditions obtained enable the method to be used for both qualitative and quantitative pharmaceutical analysis.
ISSN:	0009-5893 1612-1112
DOI:	10.1365/s10337-008-0604-8