Synthesis, Characterization and Antimicrobial Activity of Thiazolo-oxazine Fused Heterocyclic Derivatives, Based on Benzene Sulfonyl Hydrazide

Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. (1a-e) SBSZ were then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) were then condensed with 5-nitro-2furfuralidine derivatives i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These derivatives were further condensed with phenyl urea to yield fused heterocyclic derivatives i.e. N-(2-substituted-7-(5-nitrofuran-2-yl)-5-(phenylamino)-2H-thiazolo[5,4-e] [1,3]oxazin-3(3aH)-yl) benzene sulfonamide (4a-e). All the derivatives were characterised by C, H, N elemental analyser and IR-NMR-Mass Spectra. The antimicrobial properties of all the derivatives were studied for selected common microbes. The results of antibacterial activity of all three series (i.e. 2a-e, 3a-e, and 4a-e) of compounds indicate that all compounds are toxic for bacteria. However, the chlorine containing compounds are more toxic than others.