Methanol extract of Solanum violaceum root possesess antiobesity, hypolipidemic, thrombolytic and membrane stabilizing activity

Roots of Solanum violaceum (S. violaceum) is used traditionally in different therapeutic applications in Bangladesh. Root extract of S. violaceum was investigated for total phenolic content (TPC), antiobesity, anti-hyperlipidemic, membrane stability and thrombolytic activity. Total phenolic content (TPC) was determined using folin-ciocalteu method. High fat diet induced obese mice were used for anti obesity and antihyperlipidemic test. Body weight gain, blood total cholesterol, triglyceride level were analyzed. Thrombolytic and membrane stability activity were evaluated by using human erythrocytes. Total phenolic content in root extract of S. violaceum was calculated as 51.26 mg gallic acid equivalent GAE/g of dry weight. The extractive supplementation with dose of 200mg/ kg and 400mg/kg were capable of lowering the level of triglyceride and total cholesterol significantly (p