Effect of cyclophosphamide on Tyzzer's disease of mice

Experimental Tyzzer's disease of mice was enhanced by administration of cyclophosphamide (CY), showing prominent atrophy of the thymus and spleen, while necrotizing lesions were produced in the liver on Day 2 after intravenous inoculation irrespective of the drug treatment. CY-treated mice rema...

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Veröffentlicht in:	Japanese journal of veterinary science 1985, Vol.47(1), pp.81-88
Hauptverfasser:	NAKAYAMA, Hiroyuki, OGUIHARA, Sadahiko, OSAKI, Ken-ichi, TORIUMI, Wataru, FUJIWARA, Kosaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - analysis antibody bacillus Bacillus - immunology bacteriose bacterioses bacteriosis ciclofosfamida cyclophosphamide Cyclophosphamide - pharmacology Female Hepatitis, Animal - immunology immunodepresseur immunosuppressants inmunodepresores Mice mouse raton Rodent Diseases - immunology souris Tyzzer's disease
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Zusammenfassung:	Experimental Tyzzer's disease of mice was enhanced by administration of cyclophosphamide (CY), showing prominent atrophy of the thymus and spleen, while necrotizing lesions were produced in the liver on Day 2 after intravenous inoculation irrespective of the drug treatment. CY-treated mice remained antibody-negative on Day 7 when most of them died. Without the CY treatment, serum antibody increased in titers on Day 4 or later attaining a maximum level on Days 7 to 15. Infected and CY-treated mice given antibody on Day 2 survived three or more days longer than those without antibody transfer.
ISSN:	0021-5295 1881-1442
DOI:	10.1292/jvms1939.47.81