A Single-Nucleotide Polymorphism in C-Type Natriuretic Peptide Gene May Be Associated with Hypertension

We conducted an association study between genetic variants of C-type natriuretic peptide gene (CNP) and hypertension in a Japanese population. We found four genetic variants, two in the promoter region, one missense mutation, and one in the 3′-untranslated region (3′-UTR), and genotyped all four variants in 2, 006 subjects recruited from the Suita study. One of the variants, G2628A in 3′-UTR, was found to be associated with blood pressure. Multiple logistic analyses indicated that the genotype of the G2628A polymorphism (GG=1, GA+AA=2) (p =0.0034), sex (p =0.0288), alcohol consumption (p =0.0002), age (p