Nitric Oxide Buffers Renal Medullary Vasoconstriction Induced by Prostaglandins Synthesis Blockade

The aim of this study was to examine whether nitric oxide (NO) buffers the renal medullary vasoconstriction induced by a prostaglandins (PG) synthesis inhibitor. Daily blood pressure measurements were made with implanted catheters and changes in cortical blood flow (CBF) and medullary blood flow (MB...

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Veröffentlicht in:	Hypertension Research 2001, Vol.24(6), pp.699-704
Hauptverfasser:	NAKANISHI, Kazushige, CHINEN, Akira, SAITO, Yoshihito, HAMADA, Kaoru, HARA, Noriko, NAGAI, Yohko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Buffers Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - pharmacology Drug Synergism Enzyme Inhibitors - pharmacology hypertension Injections, Intravenous Kidney Medulla - blood supply Male Meclofenamic Acid - pharmacology Natriuresis - drug effects NG-Nitroarginine Methyl Ester - administration & dosage NG-Nitroarginine Methyl Ester - pharmacology nitric oxide Nitric Oxide - physiology prostaglandin Prostaglandin Antagonists - pharmacology Rats Rats, Sprague-Dawley Reference Values Regional Blood Flow - drug effects renal medullary blood flow Time Factors Vasoconstriction - physiology
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Zusammenfassung:	The aim of this study was to examine whether nitric oxide (NO) buffers the renal medullary vasoconstriction induced by a prostaglandins (PG) synthesis inhibitor. Daily blood pressure measurements were made with implanted catheters and changes in cortical blood flow (CBF) and medullary blood flow (MBF) were determined by implanted optical fibers and laser-Doppler flow measurement techniques in conscious rats. Sodium and water balance were also determined. Infusion of meclofenamate, a nonisozyme-specific cyclooxygenase (COX) inhibitor, at 5μg/kg/min over 4 consecutive days (n=12 rats) elicited a transitory increase (p
ISSN:	0916-9636 1348-4214
DOI:	10.1291/hypres.24.699