Combination of cis-platinum, oncovin, and bleomycin (cob) prior to surgery and/or radiotherapy in advanced untreated epidermoid cancer of the head and neck

A prospective study was carried out to investigate the effectiveness and feasibility of two courses of combination therapy with COB every three weeks prior to surgery and/or radiotherapy in 70 patients with advanced untreated epidermoid cancer of the head and neck. Of 65 patients evaluable after two...

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Veröffentlicht in:	The Laryngoscope 1980-08, Vol.90 (8), p.1273-1280
Hauptverfasser:	Peppard, Sean B., Al-Sarraf, Muhyi, Powers, William E., Loh, John K., Weaver, Arthur W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bleomycin - therapeutic use Carcinoma, Squamous Cell - drug therapy Cisplatin - therapeutic use Drug Therapy, Combination Evaluation Studies as Topic Female Head and Neck Neoplasms - drug therapy Humans Male Middle Aged Vincristine - therapeutic use
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Zusammenfassung:	A prospective study was carried out to investigate the effectiveness and feasibility of two courses of combination therapy with COB every three weeks prior to surgery and/or radiotherapy in 70 patients with advanced untreated epidermoid cancer of the head and neck. Of 65 patients evaluable after two courses of chemotherapy, 16 had a complete remission (CR) and 36 had a partial remission (PR; > 50% — < 100%) for a total major response rate of 80%.
ISSN:	0023-852X 1531-4995
DOI:	10.1288/00005537-198008000-00003