Studies on Coprecursors of Penicillin. Part 1

In this experiment, it is found that thhe addition of some compounds together with penicillin-G precursors into penicillin culture broth can increase or accelerate penicillin production, when compared with the single addition of penicillin G precursors. In these cases if the type of penicillin produced is chiefly penicillin G which is supposed to have been derived from penicillin G precursors, such compounds should be appreciated to improve the efficiency of penicillin G precursors. The authors have named such compounds “penicillin coprecursors” In this report, it is indicated that, among the adjuvants listed below, cystine has strong and cystein has weak coprecursor activity, but the other compounds no coprecursor activity. _??_