Suppression of D-galactosamine-induced rat liver injury by glycosidic flavonoids-rich fraction from green tea

Suppression of D-galactosamine-induced rat liver injury by glycosidic flavonoids-rich fraction from green tea

Tea constituents that had a preventive effect on D-galactosamine-induced liver injury in rats were partially purified by column chromatography from a n-butanol-soluble fraction of green tea. The fraction containing glucosidic flavonoids was found to suppress the D-galactosamine-induced increase of p...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1999-03, Vol.63 (3), p.570-572
Hauptverfasser: Wada, S. (Shizuoka Univ. (Japan). Faculty of Agriculture), He, P, Watanabe, N, Sakata, K, Sugiyama, K
Format: Artikel
Sprache:eng
Schlagworte:
Alanine Transaminase - biosynthesis
AMINO SUGARS
AMINOAZUCARES
AMINOSUCRE
Animals
Aspartate Aminotransferases - biosynthesis
Biological and medical sciences
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - prevention & control
Chromatography, High Pressure Liquid
D-galactosamine
Diet
ENFERMEDADES HEPATICAS
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - therapeutic use
Galactosamine
General pharmacology
GLICOSIDOS
GLYCOSIDE
GLYCOSIDES
green tea
Liver - enzymology
LIVER DISEASES
liver injury
MALADIE DU FOIE
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
RAT
RATA
RATS
Rats, Wistar
TEA
Tea - chemistry
THE
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Zusammenfassung:Tea constituents that had a preventive effect on D-galactosamine-induced liver injury in rats were partially purified by column chromatography from a n-butanol-soluble fraction of green tea. The fraction containing glucosidic flavonoids was found to suppress the D-galactosamine-induced increase of plasma alanine aminotransferase and aspartate aminotransferase activities. These results indicate that glucosidic flavonoids contribute, at least in part, to the liver injury-preventive effect of gre
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.63.570