Structures and Activity of Cellulase Inhibitors Enzymatically Synthesized from Cellooligosaccharides and 1-Deoxynojirimycin

Cellulase inhibitors were synthesized from cellooligosaccharides and 1-deoxynojirimycin (DNJ) by transglycosylation, using a commercial cellulase. The structures of these cellulase inhibitors were proved to be 4-O-β-cellobiosyl-DNJ, 4-O-β-D-glucopyranosyl-DNJ and 6-O-β-cellobiosyl-DNJ by the results...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1996-01, Vol.60 (2), p.344-346
Hauptverfasser:	Kawaguchi, Takeshi, Sugimoto, Kazuhisa, Hayashi, Hideo, Arai, Motoo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-deoxynojirimycin 1-Deoxynojirimycin - chemistry Analytical, structural and metabolic biochemistry Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Carbohydrate Sequence carboxymethylcellulase Cellulase - antagonists & inhibitors cellulase inhibitor Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Magnetic Resonance Spectroscopy Methods. Procedures. Technologies Molecular Sequence Data Oligosaccharides - chemistry Spectrometry, Mass, Fast Atom Bombardment Structure-Activity Relationship transglycosylation
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Beschreibung
Zusammenfassung:	Cellulase inhibitors were synthesized from cellooligosaccharides and 1-deoxynojirimycin (DNJ) by transglycosylation, using a commercial cellulase. The structures of these cellulase inhibitors were proved to be 4-O-β-cellobiosyl-DNJ, 4-O-β-D-glucopyranosyl-DNJ and 6-O-β-cellobiosyl-DNJ by the results of 13 C- and 1 H-NMR analyses. The inhibitory activity of each inhibitor was investigated against several carboxymethylcellulases.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.60.344