Measurement of a 5-gene panel in whole blood in kidney transplant recipients with acute rejection and stable controls [version 2; peer review: 1 approved, 1 approved with reservations]

Measurement of a 5-gene panel in whole blood in kidney transplant recipients with acute rejection and stable controls [version 2; peer review: 1 approved, 1 approved with reservations]

New biomarkers are required to detect acute rejection (AR) in kidney transplant recipients (KTRs) to avoid invasive kidney biopsies. We assess whether a 5-gene panel ( DUSP1; NKTR; PBEF1; MAPK9; and PSEN1) in whole blood samples that has previously been shown to identify AR in a paedriatric KTR popu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:F1000 research 2016, Vol.4, p.913
Hauptverfasser: Betts, Gareth, Van Der Net, Jeroen, Shankar, Sushma, Friend, Peter, Harden, Paul, Wood, Kathryn
Format: Artikel
Sprache:eng
Schlagworte:
Dialysis & Renal Transplantation
Medical Genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:New biomarkers are required to detect acute rejection (AR) in kidney transplant recipients (KTRs) to avoid invasive kidney biopsies. We assess whether a 5-gene panel ( DUSP1; NKTR; PBEF1; MAPK9; and PSEN1) in whole blood samples that has previously been shown to identify AR in a paedriatric KTR population is able to distinguish AR in a UK population of adult Caucasian KTR patients.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.6941.2