Cutaneous transmissible venereal tumor with internal metastases in two dogs

Two intact male dogs, a 6-ycar-old Siberian husky (case one) and an 18-year-old Old Fnglish sheepdog-cross (case two), were admitted to the Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thcssaloniki (AUTh), with a single or multiple cutaneous masses, respectively. Fine needle aspiration (FNA) smears obtainedfrom the masses revealed the typical cytological features of transmissible venereal tumor (TVT) in both instances, while Leishmania infantum infection was diagnosed in the second case. In both dogs, distant metastases within the spleen and liver were diagnosed by ultra sonography-assisted FN A cytology, laparotomy-facilitated hi stop atho logy and computed tomography (case one) or post-mortem cytology and histopathology (case two). Vincristine sulphate (two weekly sessions) followed by doxorubicin chemotherapy (five .1-week sessions) failed to achieve clinical remission in case one, while the dog in case two was euthanized without any therapeutic effort. This study describes the clinical, imaging, cytologic and pathologic findings of two dogs with primary cutaneous TVT metastasized internally, Chemotherapy resistance, rarely recorded in TVT, was documented in one of them, whereas concurrent Leishmania infection in the other dog might have provoked the dissemination of TVT presumably due to the Le is h mania associated immunosuppression.