Effect of Ketotifen on Acute Gastric Lesions and Gastric Secretion in Rats

Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the hi...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1992, Vol.59(2), pp.251-254
Hauptverfasser:	Okabe, Susumu, Nakaji, Shigeru, Tachibana, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute gastric lesions Animals Aspirin - toxicity Biological and medical sciences Cytoprotection Ethanol - toxicity Gastric Acid - metabolism Gastric Mucosa - drug effects Gastric Mucosa - injuries Gastric Mucosa - metabolism Histamine - toxicity Ketotifen Ketotifen - pharmacology Male Medical sciences p-Methoxy-N-methylphenethylamine - toxicity Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Respiratory system
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Beschreibung
Zusammenfassung:	Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.59.251