EFFECTS OF YS-980, AN ORALLY ACTIVE CONVERTING ENZYME INHIBITOR, ON BLOOD PRESSURE IN NORMOTENSIVE AND HYPERTENSIVE RATS

The hypotensive effect of YS-980, (4R)-3-[(2S)-3-mercapto-2-methyl propanoyl]-4-thiazolidinecarboxylic acid, was investigated in normotensive and different models of hypertensive rats. Experiments were carried out in both anesthetized rats (1 mg/kg i.v.), and conscious unrestrained rats (10 mg/kg p.o.). YS-980 markedly lowered blood pressure in acute renal hypertensive and two-kidney, one-clip hypertensive rats and moderately lowered the pressure in SHR. Contrary to these hypotensive effects, this agent did not reduce the blood pressure in DOCA hypertensive rats. In normotensive rats, YS-980 had a slight hypotensive action in anesthetized rats but not in the conscious animals. The hypotensive effect of YS-980 is attributed mainly to suppression of the reninangiotensin system.